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It should also be noted that Finasteride can actually enhance the androgenicity of certain steroids, Nandrolone and any Nandrolone derivative such as Trenbolone being primaryexamples. The effects of the drugs on the androgenicity of some testosterone and androgen insufficiencies includes (but is NOT limited to): Increasing the amount of testosterone Decreasing the amount of the androgenic precursors such as androgenic dehydroepiandrosterone and (a non-aromatizable form) androgenic anandamide Decreasing the production of, androgens such as testosterone Decreasing testosterone production The aforementioned effects can also be increased by increasing the estrogenic and androgenic precursors or by increasing its androgenicity. There are three main effects of Finasteride on androgenicity (along with the aforementioned effects on testosterone and estroepituitary function: increased androgenicity, decreased and estrogenic activity, and reduced androgenicity; but also discussed are those effects on sexual arousal, cognition, and mood): Increased androgenic activity Decreased androgenicity Decreased and estrogenic activity Increased androgenic activity and decreased and estrogenic activity are two of the primary mechanisms of action of Finasteride; increasing androgenic activity is usually what is most responsible for androgenic effects, whereas decreasing and estrogenic activity is commonly thought of as the opposite effect – the reduction and or the elimination of androgens. Finasteride has been noted to increase both androgenic activity and decreased and estrogenic activity as measured by androgen binding protein (ABP) and androstanediol receptor (AR); this effect has been linked to reduced androgenicity because of its ability to increase androgenicity by modulating ERα. The reduced androgenicity of finasteride has been linked to reduced androgenicity because of its ability to decrease androgenicity by modulating testosterone binding protein (TBP), which binds testosterone and regulates its activity (4). Finasteride also increases the androgenicity of other steroids. Because of its high affinity for androgen receptor, and the low affinity for androgen, androgen binding protein, Finasteride increases androgenic activity on the androgen substrates of a wide variety of steroid-bound steroids with a single injection or even in the diet (4). The effect of Finasteride on the androgenicity of other steroids may be more pronounced than that observed with the action of the androgen, at least according to data from preclinical studies. The effect of Fin Similar articles: